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Description for Protein BST1

bone marrow stromal cell antigen 1
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.2.5
    KEGG - Orthology:
    K01242
    KEGG - Pathway(s):
    hsa00760; hsa01100; hsa04020; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD157 antigen; Cyclic ADP ribose hydrolase 2; cADPr hydrolase 2; ADP ribosyl cyclase 2; EC 3.2.2.5
    Approved Symbol:
    BST1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate Monothiophosphate(db);
  • Etheno-Nad(db);
  • Etheno-Nadp(db);
  • Nicotinamide(db);
  • Nicotinamide Mononucleotide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02665 Entrez Gene ID: 683 OMIM ID: 600387 Swissprot Accession: Q10588;