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Description for Protein STK11

serine/threonine kinase 11
27 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.9
    KEGG - Orthology:
    K07298
    KEGG - Pathway(s):
    hsa04150; hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PJS; Serine/Threonine protein kinase 11
    Approved Symbol:
    STK11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 18
    Human phosphorylation targets: 18; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Melanoma, sporadic malignant(Pd);
  • Pancreatic cancer, sporadic(Pd);
  • Peutz-Jeghers syndrome(Pd);
  • Testicular tumor, sporadic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03740 Entrez Gene ID: 6794 OMIM ID: 602216 Swissprot Accession: Q15831;