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Description for Protein STK3

serine/threonine kinase 3
17 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 5)
Summary:
Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996 [PubMed 8816758]; Lee et al., 2001 [PubMed 11278283]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.5
    KEGG - Orthology:
    K04412
    KEGG - Pathway(s):
    hsa04010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    STE20 like kinase MST2; MST2; Mammalian STE20 like protein kinase 2; Serine/threonine protein kinase Krs1; Kinase responsive to stress 1; KRS1; EC 2.7.11.1
    Approved Symbol:
    STK3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 6; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05433 Entrez Gene ID: 6788 OMIM ID: 605030 Swissprot Accession: Q13188;