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Description for Protein STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)
122 total interacting proteins; 61 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 2; microparticles: 1; platelet: 1; secretome: 3)
Summary:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04692
    KEGG - Pathway(s):
    hsa04062; hsa04630; hsa04920; hsa05200; hsa05212; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Signal transducer and activator of transcription 3 isoform 2; STAT3B; STAT3beta; Signal transducer and activator of transcription 3 isoform 3; Signal transducer and activator of transcription 3 isoform 1; Signal transducer and activator of transcription 3; Acute phase response factor; APRF
    Approved Symbol:
    STAT3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00026 Entrez Gene ID: 6774 OMIM ID: 102582 Swissprot Accession: P40763;