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Description for Protein STAT1

signal transducer and activator of transcription 1, 91kDa
92 total interacting proteins; 45 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 8; secretome: 3)
Summary:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11220
    KEGG - Pathway(s):
    hsa04062; hsa04620; hsa04630; hsa05140; hsa05200; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Signal transducer and activator of transcription 1; Transcription factor ISGF 3; p91; Signal transducer and activator of transcription 1 isoform beta; Signal transducer and activator of transcription 1 isoform alpha
    Approved Symbol:
    STAT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Atypical mycobacterial infection, familial disseminated(Pd);
  • STAT1 deficiency, complete(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02777 Entrez Gene ID: 6772 OMIM ID: 600555 Swissprot Accession: P42224;