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Description for Protein ST14

suppression of tumorigenicity 14 (colon carcinoma)
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • LDLA: Low-density lipoprotein receptor domain class A
  • TM: Transmembrane domain
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.109
    KEGG - Orthology:
    K08670
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Suppressor of tumorigenicity 14; MTSP1; Membrane type serine protease 1; MT SP1; Prostamin; Serine protease TADG 15; TADG15; SNC19; PRSS14
    Approved Symbol:
    ST14
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Benzamidine(db);
  • Urokinase(db)

    Associated Genetic Diseases:

  • Ichthyosis with hypotrichosis, autosomal recessive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 06005 Entrez Gene ID: 6768 OMIM ID: 606797 Swissprot Accession: Q9Y5Y6;