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Description for Protein ST13

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
11 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(microparticles: 1; phosphoproteome: 1; platelet: 4; secretome: 1; undefined: 1)
Summary:
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TPR: Tetratricopeptide repeats
  • CC: Coiled Coil
  • STI1: Heat shock chaperonin-binding motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09560
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Hip; HOP; P48; SNC6; HSPABP1; FAM10A1; PRO0786; Putative tumor suppressor ST13; Suppression of tumorigenicity 13; Heat shock 70kD protein binding protein; Progesterone receptor associated p48 protein
    Approved Symbol:
    ST13
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08426 Entrez Gene ID: 6767 OMIM ID: 606796 Swissprot Accession: P50502; Q2TU77;