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Description for Protein BRCA2

breast cancer 2, early onset
39 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K08775
KEGG - Pathway(s):
hsa03440; hsa05200; hsa05212
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Breast cancer type 2 susceptibility protein; Breast cancer 2, early onset; FAD; FACD; FAD1; FANCB; FANCD; FANCD1
Approved Symbol:
BRCA2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 14
Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Breast cancer(Pd);
  • Breast cancer 2, early-onset(Pd);
  • Breast cancer, type 2, susceptibility to(Pd);
  • Fanconi anemia, complementation group D1(Pd);
  • Prostate cancer(Pd);
  • Wilms tumor(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02554 Entrez Gene ID: 675 OMIM ID: 600185 Swissprot Accession: P51587;