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Description for Protein TRIM21

tripartite motif-containing 21
16 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • RING: Ring finger
  • PRY: Parathyroid hormone
  • SPRY: Domain in SPla and the RYanodine Receptor.
  • BBOX: B-Box-type zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10651
    KEGG - Pathway(s):
    hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sicca syndrome antigen A; SSA; Autoantigen R0/SSA 52KD; R052; Autoantigen p27; 52 KDa R0 protein; Sjogren syndrome type A antigen; R0(SS-A); 52 KDa ribonucleoprotein autoantigen R0/SS-A; TRIM 21; Sjogren syndrome antigen A1
    Approved Symbol:
    TRIM21
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00170 Entrez Gene ID: 6737 OMIM ID: 109092 Swissprot Accession: P19474;