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Description for Protein SRP72

signal recognition particle 72kDa
7 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The SRP72 gene encodes the 72-kD subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of proteins to the endoplasmic reticulum (ER) (summarized by Lutcke et al., 1993 [PubMed 8388879]). The complex consists of a 7S (or 7SL) RNA and 6 different proteins, SRP9 (MIM 600707), SRP14 (MIM 600708), SRP19 (MIM 182175), SRP54 (MIM 604857), SRP68 (MIM 604858), and SRP72. The proteins are bound to the 7S RNA as monomers (SRP19 and SRP54) or heterodimers (SRP9/SRP14 and SRP68/SRP72). SRP9 and SRP14 constitute the Alu domain of 7S, whereas the other 4 proteins belong to the S domain. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TPR: Tetratricopeptide repeats
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03108
    KEGG - Pathway(s):
    hsa03060
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Signal recognition particle 72 KDa protein
    Approved Symbol:
    SRP72
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03671 Entrez Gene ID: 6731 OMIM ID: 602122 Swissprot Accession: O76094; Q7Z3C0;