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Description for Protein BRAF

v-raf murine sarcoma viral oncogene homolog B1
28 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RBD: Raf-like Ras-binding domain
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04365
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04150; hsa04270; hsa04510; hsa04650; hsa04720; hsa04722; hsa04730; hsa04810; hsa04910; hsa04914; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Oncogene BRAF; BRAF1; RAFB1; Rmil; B-Raf proto-oncogene serine/threonine-protein kinase; MGC126806; MGC138284; EC 2.7.11.1; p94
    Approved Symbol:
    BRAF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 27
    Human (de-) phosphorylation sites: 27; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime(db);
  • 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE(db);
  • N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide(db);
  • N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide(db);
  • Sorafenib(db)

    Associated Genetic Diseases:

  • Adenocarcinoma of lung, somatic(Pd);
  • Cardiofaciocutaneous syndrome(Pd);
  • Colon cancer, somatic(Pd);
  • Colorectal cancer, somatic(Pd);
  • Lymphoma, non-Hodgkin(Pd);
  • Melanoma, malignant, somatic(Pd);
  • Nonsmall cell lung cancer, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01264 Entrez Gene ID: 673 OMIM ID: 164757 Swissprot Accession: P15056;