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Description for Protein SRC

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
249 total interacting proteins; 140 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 12/1)
(alpha granules: 1; ATP binding: 1; membrane: 3; microparticles: 1; phosphoproteome: 1; platelet: 6; secretome: 2; undefined: 1)
Summary:
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K05704
    KEGG - Pathway(s):
    hsa04012; hsa04144; hsa04370; hsa04510; hsa04520; hsa04530; hsa04540; hsa04912; hsa05100; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Src; Avian sarcoma virus protein; ASV; p60-Src; Tyrosine kinase pp60c-src; Tyrosine protein kinase SRC-1; Protooncogene SRC, Rous sarcoma; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; Proto-oncogene tyrosine-protein kinase SRC; EC 2.7.1.112; pp60c-src
    Approved Symbol:
    SRC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 171
    Human phosphorylation targets: 168; Predicted platelet targets: 5
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide(db);
  • 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine(db);
  • 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine(db);
  • 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine(db);
  • 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine(db);
  • 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea(db);
  • 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea(db);
  • 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE(db);
  • 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL(db);
  • 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE(db);
  • Citric Acid(db);
  • Cysteine Sulfenic Acid(db);
  • Dasatinib(db);
  • DPI59(db);
  • ISO24(db);
  • Malonic acid(db);
  • N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE(db);
  • N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE(db);
  • N6-Benzyl Adenosine-5'-Diphosphate(db);
  • Oxalic Acid(db);
  • PAS219(db);
  • PASBN(db);
  • Phenylphosphate(db);
  • Phosphonotyrosine(db);
  • Purvalanol A(db);
  • RU78191(db);
  • RU78262(db);
  • RU78299(db);
  • RU78300(db);
  • RU78783(db);
  • RU79072(db);
  • RU79073(db);
  • RU79256(db);
  • RU81843(db);
  • RU82129(db);
  • RU82197(db);
  • RU82209(db);
  • RU83876(db);
  • RU84687(db);
  • RU85053(db);
  • RU85493(db);
  • RU90395(db);
  • [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile(db)

    Associated Genetic Diseases:

  • Colon cancer, advanced(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01819 Entrez Gene ID: 6714 OMIM ID: 190090 Swissprot Accession: P12931;