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Description for Protein SPTBN1

spectrin, beta, non-erythrocytic 1
35 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(microparticles: 1; phosphoproteome: 1; platelet: 4; undefined: 1)
Summary:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SPECTRIN: Spectrin repeat
  • CC: Coiled Coil
  • CH: Calponin homology domain
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06115
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Spectrin nonerythroid beta subunit; SPTB2; Fodrin beta chain; Beta II spectrin; Spectrin beta II; Spectrin beta nonerythrocytic 1; Spectrin beta non-erythrocytic 1 isoform 2; Spectrin beta non-erythrocytic 1 isoform 1
    Approved Symbol:
    SPTBN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 90
    Human (de-) phosphorylation sites: 90; Platelet phosphorylation sites: 4
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Calcium(db);
  • D-Myo-Inositol-1,4,5-Triphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01683 Entrez Gene ID: 6711 OMIM ID: 182790 Swissprot Accession: Q01082; B2ZZ89;