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Description for Protein BPGM

2,3-bisphosphoglycerate mutase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.1.3.13; 5.4.2.1; 5.4.2.4
KEGG - Orthology:
K01837
KEGG - Pathway(s):
hsa00010; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
2,3-DPG mutase; DPGM; DPGAM; Bisphosphoglyceromutase; 2,3-bisphosphoglycerate phosphatase; 2,3-BPG phosphatase; EC 5.4.2.4; EC 5.4.2.1; EC 3.1.3.13; BPG-dependent PGAM
Approved Symbol:
BPGM
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Bisphosphoglyceromutase deficiency, hemolytic anemia due to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01961 Entrez Gene ID: 669 OMIM ID: 222800 Swissprot Accession: P07738; A4D1N9;