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Description for Protein SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1
38 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ETS: erythroblast transformation specific domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09438
    KEGG - Pathway(s):
    hsa05200; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Spleen focus forming virus proviral integration oncogene SPI1; Oncogene SPI1; Hematopoietic transcription factor PU.1; 31 kDa transforming protein; PU.1; hCG_25181; OF; SFPI1; SPI-A; Hematopoietic transcription factor PU.1 isoform 1; Hematopoietic transcription factor PU.1 isoform 2
    Approved Symbol:
    SPI1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01305 Entrez Gene ID: 6688 OMIM ID: 165170 Swissprot Accession: P17947;