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Description for Protein FOXL2

forkhead box L2
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FH: FORKHEAD
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09405
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Forkhead transcription factor FOXL2
    Approved Symbol:
    FOXL2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Blepharophimosis, ptosis, and epicanthus inversus(Pd);
  • Blepharophimosis, ptosis, and epicanthus inversus, type I(Pd);
  • Blepharophimosis, ptosis, and epicanthus inversus, type II(Pd);
  • Premature ovarian failure 3(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05723 Entrez Gene ID: 668 OMIM ID: 605597 Swissprot Accession: P58012; Q53ZD3;