Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein DST

dystonin
13 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 2)
Summary:
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • SPECTRIN: Spectrin repeat
  • CH: Calponin homology domain
  • EF: EF-hand, calcium binding motif
  • SH3: Src homology 3 domains
  • PLEC: Plectin repeat
  • GAS2: Growth-Arrest-Specific Protein 2 Domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10382
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    BP240; BPA; MACF2; CATX15; FLJ13425; FLJ21489; FLJ30627; FLJ32235; KIAA0728; Trabeculin-beta; 230/240 kDa bullous pemphigoid antigen; Hemidesmosomal plaque protein; Dystonia musculorum protein; Dystonin; DMH; Dystonin isoform 1e; Dystonin isoform 1eA; Dystonin isoform 1eB; Dystonin isoform 1
    Approved Symbol:
    DST
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 129
    Human (de-) phosphorylation sites: 129; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 1
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00222 Entrez Gene ID: 667 OMIM ID: 113810 Swissprot Accession: Q86T18; B4DGY0; Q6P0N6;