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Description for Protein SOS1

son of sevenless homolog 1 (Drosophila)
55 total interacting proteins; 28 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03099
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04320; hsa04510; hsa04540; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04722; hsa04810; hsa04910; hsa04912; hsa05200; hsa05211; hsa05213; hsa05214; hsa05215; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SOS1 guanine nucleotide exchange factor; Son of sevenless, homolog 1; GF1; GGF1; GINGF; HGF; NS4; Gingival fibromatosis, hereditary, 1; Gingival fibromatosis
    Approved Symbol:
    SOS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Fibromatosis, gingival, 1(Pd);
  • Noonan syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01681 Entrez Gene ID: 6654 OMIM ID: 182530 Swissprot Accession: Q07889;