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Description for Protein SOD2

superoxide dismutase 2, mitochondrial
8 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(microparticles: 1; platelet: 5; secretome: 1)
Summary:
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.15.1.1
KEGG - Orthology:
K04564
KEGG - Pathway(s):
hsa04146; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
MNSOD; Mn-SOD; Mn superoxide dismutase; Mangano-superoxide dismutase; SODM; Manganese-containing superoxide dismutase; Manganese superoxide dismutase isoform A; Manganese superoxide dismutase isoform B; Superoxide dismutase 2; Superoxide dismutase, mitochondrial; Indophenoloxidase B; IPO-B; Manganese superoxide dismutase; EC 1.15.1.1
Approved Symbol:
SOD2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-Fluorotyrosine(db);
  • Acetate Ion(db);
  • Benzylsulfinic Acid(db);
  • Beta-Mercaptoethanol(db)

    Associated Genetic Diseases:

  • Superoxide dismutase 2 polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00938 Entrez Gene ID: 6648 OMIM ID: 147460 Swissprot Accession: P04179; B4DL20;