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Description for Protein SOD1

superoxide dismutase 1, soluble
14 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(platelet: 4; secretome: 1)
Summary:
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.15.1.1
KEGG - Orthology:
K04565
KEGG - Pathway(s):
hsa04146; hsa05014; hsa05016; hsa05020
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Superoxide dismutase 1; Superoxide dismutase, cystolic; Superoxide dismutase, soluble; SOD, soluble; Superoxide dismutase, copper-zinc; Indophenoloxidase A; IPOA; EC 1.15.1.1
Approved Symbol:
SOD1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • S-Oxy Cysteine(db)

    Associated Genetic Diseases:

  • Amyotrophic lateral sclerosis 1(Pd);
  • Amyotrophic lateral sclerosis 1, autosomal recessive(Pd);
  • Amyotrophic lateral sclerosis, sporadic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00937 Entrez Gene ID: 6647 OMIM ID: 147450 Swissprot Accession: P00441;