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Description for Protein SNCA

synuclein, alpha (non A4 component of amyloid precursor)
76 total interacting proteins; 49 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(microparticles: 1; platelet: 4)
Summary:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04528
KEGG - Pathway(s):
hsa05010; hsa05012
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PD1; PARK1; PARK4; Alpha-synuclein isoform NACP140; Alpha-synuclein isoform NACP112; NACP; Non-A4 component of amyloid; Non-A beta component of AD amyloid; Alpha synuclein
Approved Symbol:
SNCA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Dementia, lewy body(Pd);
  • Parkinson disease 1(Pd);
  • Parkinson disease 4, autosomal dominant lewy body(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01227 Entrez Gene ID: 6622 OMIM ID: 163890 Swissprot Accession: P37840;