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Description for Protein SMARCC2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
37 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CHROMO: Chromatin organization modifier domain
  • SANT: SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11649
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Rsc8; BAF170; CRACC2; SWI3-like protein; SWI/SNF complex 170 kDa subunit; Chromatin remodeling complex BAF170 subunit; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2; SWI/SNF related matrix associated actin dependent regulator of chromatin c2 isoform a; SWI/SNF related matrix associated actin dependent regulator of chromatin c2 isoform b
    Approved Symbol:
    SMARCC2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03437 Entrez Gene ID: 6601 OMIM ID: 601734 Swissprot Accession: Q8TAQ2; Q59GV3;