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Description for Protein BMX

BMX non-receptor tyrosine kinase
17 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified. (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K08896
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Bone marrow kinase; Bone marrow kinase, X-linked; Protein tyrosine kinase BMX; Cytoplasmic tyrosine-protein kinase; BMX non-receptor tyrosine kinase; Epithelial and endothelial tyrosine kinase; ETK; NTK38; PSCTK2; PSCTK3; EC 2.7.1.112
    Approved Symbol:
    BMX
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02111 Entrez Gene ID: 660 OMIM ID: 300101 Swissprot Accession: P51813;