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Description for Protein SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
94 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HELIC: helicase superfamily c-terminal domain
  • BROMO: bromo domain
  • CC: Coiled Coil
  • BRK: domain in transcription and CHROMO domain helicases
  • DEXDc: DEAD-like helicases superfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K11647
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4; BRM/SWI2 related gene 1; BRG1; SNF2 beta; BAF190; SNF2L4; SNF2LB
    Approved Symbol:
    SMARCA4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 83
    Human (de-) phosphorylation sites: 83; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04459 Entrez Gene ID: 6597 OMIM ID: 603254 Swissprot Accession: B1A8Z7; P51532; B3KNW7;