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Description for Protein HLTF

helicase-like transcription factor
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • NLS: Nuclear localization signal
  • RING: Ring finger
  • HELIC: helicase superfamily c-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DNA-binding protein/plasminogen activator inhibitor-1 regulator; SNF2-like 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3; Alternative translation initiation; Sucrose nonfermenting-like 3; HLTF1; RNF80; HIP116A; EC 3.6.1.-; Helicase like transcription factor; HIP116; SNF2L3; ZBU1
    Approved Symbol:
    HLTF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04461 Entrez Gene ID: 6596 OMIM ID: 603257 Swissprot Accession: Q14527; Q05BZ6;