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Description for Protein SLC22A4

solute carrier family 22 (organic cation/ergothioneine transporter), member 4
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08201
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Solute carrier family (Organic cation transporter), member 4; OCTN1; Organic cation transporter 4; Integral membrane transport protein; OCT1
    Approved Symbol:
    SLC22A4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Carnitine(db)

    Associated Genetic Diseases:

  • Crohn disease, susceptibility to(Pd);
  • Rheumatoid arthritis, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
    09171_1(11)
    Additional Identifiers:

    HPRD: 09171 Entrez Gene ID: 6583 OMIM ID: 604190 Swissprot Accession: Q9H015;