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Description for Protein SLC18A2

solute carrier family 18 (vesicular monoamine), member 2
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; phosphoproteome: 1; undefined: 1)
Summary:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08155
    KEGG - Pathway(s):
    hsa05012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Vesicular amine transporter 2; Vesicular monoamine transporter 2; VAT2; VMAT2; Solute carrier family 18 member 2; Synaptic vesicular amine transporter brain; SVAT; Synaptic vesicular monoamine transporter brain; SVMT; Monoamine transporter; Synaptic vesicular amine transporter
    Approved Symbol:
    SLC18A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,4-Methylenedioxymethamphetamine(db);
  • 4-Methoxyamphetamine(db);
  • Alseroxylon(db);
  • Amphetamine(db);
  • Benzphetamine(db);
  • Deserpidine(db);
  • Dextroamphetamine(db);
  • Ephedra(db);
  • Ephedrine(db);
  • Isometheptene(db);
  • Methamphetamine(db);
  • MMDA(db);
  • Propylhexedrine(db);
  • Reserpine(db);
  • Tetrabenazine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    01896_1(11)
    Additional Identifiers:

    HPRD: 01896 Entrez Gene ID: 6571 OMIM ID: 193001 Swissprot Accession: Q05940;