Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein SLC16A2

solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an integral membrane protein transporter of thyroid hormone; specifically, cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues including brain, heart, placenta, lung, kidney, skeletal muscle, and liver. This gene likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08231
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Solute carrier famliy 16 monocarboxilic acid transporter member 2; XPCT; DXS128E; MCT 8; X-linked PEST containing transporter; MCT 7; Monocarboxylate transporter 8
    Approved Symbol:
    SLC16A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Pyruvic acid(db)

    Associated Genetic Diseases:

  • Allan-Herndon-Dudley syndrome(Pd)
    		• Predicted Transmembrane Domains:
    02106_1(11)
    Additional Identifiers:

    HPRD: 02106 Entrez Gene ID: 6567 OMIM ID: 300095 Swissprot Accession: P36021; B1ALU8;