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Description for Protein SLC16A1

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08179
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MCT 1; Monocarboxylate transporter 1
    Approved Symbol:
    SLC16A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Pyruvic acid(db)

    Associated Genetic Diseases:

  • Erythrocyte lactate transporter defect(Pd)
    		• Predicted Transmembrane Domains:
    02816_1(11)
    Additional Identifiers:

    HPRD: 02816 Entrez Gene ID: 6566 OMIM ID: 600682 Swissprot Accession: P53985; B4DKS0; Q5T8R6;