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Description for Protein SLC12A2

solute carrier family 12 (sodium/potassium/chloride transporters), member 2
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
By moving chloride into epithelial cells, the Na-K-Cl cotransporter SLC12A2 aids transcellular movement of chloride across both secretory and absorptive epithelia (Payne et al., 1995 [PubMed 7629105]). See also SLC12A1 (MIM 600839) and SLC12A3 (MIM 600968).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10951
    KEGG - Pathway(s):
    hsa04970; hsa05110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BSC; BSC2; NKCC1; Basolateral Na-K-Cl symporter; Bumetanide sensitive sodium potassium chloride cotransporter 1
    Approved Symbol:
    SLC12A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Bumetanide(db);
  • Potassium Chloride(db);
  • Quinethazone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    06775_1(12)
    Additional Identifiers:

    HPRD: 06775 Entrez Gene ID: 6558 OMIM ID: 600840 Swissprot Accession: Q53ZR1; P55011;