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Description for Protein SLC9A1

solute carrier family 9 (sodium/hydrogen exchanger), member 1
14 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; phosphoproteome: 1; undefined: 1)
Summary:
The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others (Mattei et al., 1988 [PubMed 2846238]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05742
    KEGG - Pathway(s):
    hsa04260; hsa04810; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Antiporter sodium-hydrogen ion, amiloride sensitive; APNH; Sodium/hydrogen exchanger 1; Na(+)/H(+) exchanger 1; NHE1; Na+/H+ antiporter; Na+/H+ antiporter, amiloride sensitive
    Approved Symbol:
    SLC9A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 23
    Human (de-) phosphorylation sites: 23; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amiloride(db);
  • Homoserine Lactone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    00123_1(12)
    Additional Identifiers:

    HPRD: 00123 Entrez Gene ID: 6548 OMIM ID: 107310 Swissprot Accession: P19634; B2RAH2;