Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05849
    KEGG - Pathway(s):
    hsa04020
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Na+/Ca2+ exchanger isoform 3; Solute carrier family 8 member 3 isoform C precursor; Solute carrier family 8 member 3 isoform A precursor; Solute carrier family 8 member 3 isoform B precursor; Solute carrier family 8 member 3 isoform D precursor; Solute carrier family 8 member 3 isoform F; NCX3; Sodium-calcium exchanger 3; Sodium/calcium exchanger SLC8A3
    Approved Symbol:
    SLC8A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 5
  • Isoform 6 : 5
  • Isoform 5 : 6
    09723_4(11)
    09723_3(11)
    09723_2(11)
    09723_1(11)
    • Additional Identifiers:

    HPRD: 09723 Entrez Gene ID: 6547 OMIM ID: 607991 Swissprot Accession: P57103; Q96QG2; Q5K3P6;