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Description for Protein SLC6A4

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
5 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(membrane: 1; undefined: 2)
Summary:
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05037
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    HTT; Serotonin transporter; 5-hydroxytryptamine transporter; 5HT transporter; Sodium dependent serotonin transporter; 5HTT; SERT
    Approved Symbol:
    SLC6A4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,4-Methylenedioxymethamphetamine(db);
  • 4-Methoxyamphetamine(db);
  • Amineptine(db);
  • Amitriptyline(db);
  • Amoxapine(db);
  • Atomoxetine(db);
  • Chlorpheniramine(db);
  • Citalopram(db);
  • Clomipramine(db);
  • Cocaine(db);
  • Desipramine(db);
  • Desvenlafaxine(db);
  • Dexfenfluramine(db);
  • Dexmethylphenidate(db);
  • Dextromethorphan(db);
  • Doxepin(db);
  • Duloxetine(db);
  • Ephedra(db);
  • Escitalopram(db);
  • Fenfluramine(db);
  • Fluoxetine(db);
  • Fluvoxamine(db);
  • Imipramine(db);
  • Mazindol(db);
  • Methamphetamine(db);
  • Methylphenidate(db);
  • Mianserin(db);
  • Milnacipran(db);
  • Minaprine(db);
  • MMDA(db);
  • Nefazodone(db);
  • Nortriptyline(db);
  • Paroxetine(db);
  • Phentermine(db);
  • Protriptyline(db);
  • Pseudoephedrine(db);
  • Sertraline(db);
  • Sibutramine(db);
  • Tramadol(db);
  • Trazodone(db);
  • Trimipramine(db);
  • Venlafaxine(db);
  • Verapamil(db);
  • Zimelidine(db)

    Associated Genetic Diseases:

  • Serotonin transporter activity, increased/decreased(Pd)
    		• Predicted Transmembrane Domains:
    01640_1(12)
    Additional Identifiers:

    HPRD: 01640 Entrez Gene ID: 6532 OMIM ID: 182138 Swissprot Accession: B2R7Y7; P31645; Q5EE02;