Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein SLC6A3

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
12 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05036
    KEGG - Pathway(s):
    hsa05012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dopamine transporter; Sodium-dependent dopamine transporter; DAT; DAT1; DA transporter
    Approved Symbol:
    SLC6A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,4-Methylenedioxymethamphetamine(db);
  • 4-Methoxyamphetamine(db);
  • Amphetamine(db);
  • Benzphetamine(db);
  • Benztropine(db);
  • Bupropion(db);
  • Chloroprocaine(db);
  • Chlorpheniramine(db);
  • Cocaine(db);
  • Dexmethylphenidate(db);
  • Dextroamphetamine(db);
  • Diethylpropion(db);
  • Diphenylpyraline(db);
  • Dopamine(db);
  • Duloxetine(db);
  • Ephedra(db);
  • Escitalopram(db);
  • Fencamfamine(db);
  • Lisdexamfetamine(db);
  • Mazindol(db);
  • Methamphetamine(db);
  • Methylphenidate(db);
  • MMDA(db);
  • Modafinil(db);
  • Nefazodone(db);
  • Nomifensine(db);
  • Phenmetrazine(db);
  • Phentermine(db);
  • Procaine(db);
  • Pseudoephedrine(db);
  • Sertraline(db);
  • Sibutramine(db);
  • Trimipramine(db);
  • Venlafaxine(db)

    Associated Genetic Diseases:

  • Nicotine dependence, protection against(Pd)
    		• Predicted Transmembrane Domains:
    00543_1(12)
    Additional Identifiers:

    HPRD: 00543 Entrez Gene ID: 6531 OMIM ID: 126455 Swissprot Accession: A2RUN4; Q01959;