Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein SLC6A2

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05035
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NET1; Sodium dependent noradrenaline transporter; Norepinephrine transporter protein 1; Solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5; Neurotransmitter transporter, noradrenaline; NAT1; NET
    Approved Symbol:
    SLC6A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,4-Methylenedioxymethamphetamine(db);
  • Amineptine(db);
  • Amitriptyline(db);
  • Amoxapine(db);
  • Atomoxetine(db);
  • Bupropion(db);
  • Chlorpheniramine(db);
  • Clomipramine(db);
  • Cocaine(db);
  • Debrisoquin(db);
  • Desipramine(db);
  • Desvenlafaxine(db);
  • Dexmethylphenidate(db);
  • Dextroamphetamine(db);
  • Diethylpropion(db);
  • Doxepin(db);
  • Duloxetine(db);
  • Ephedra(db);
  • Ephedrine(db);
  • Ergotamine(db);
  • Escitalopram(db);
  • Ginkgo biloba(db);
  • Guanadrel Sulfate(db);
  • Guanethidine(db);
  • Imipramine(db);
  • Levonordefrin(db);
  • Maprotiline(db);
  • Mazindol(db);
  • Methamphetamine(db);
  • Methylphenidate(db);
  • Mianserin(db);
  • Milnacipran(db);
  • MMDA(db);
  • Nefazodone(db);
  • Nomifensine(db);
  • Nortriptyline(db);
  • Orphenadrine(db);
  • Paroxetine(db);
  • Phendimetrazine(db);
  • Phenmetrazine(db);
  • Phentermine(db);
  • Protriptyline(db);
  • Pseudoephedrine(db);
  • Reboxetine(db);
  • Sibutramine(db);
  • Tramadol(db);
  • Trimipramine(db);
  • Venlafaxine(db)

    Associated Genetic Diseases:

  • Orthostatic intolerance(Pd)
    		• Predicted Transmembrane Domains:
    01232_1(12)
    Additional Identifiers:

    HPRD: 01232 Entrez Gene ID: 6530 OMIM ID: 163970 Swissprot Accession: P23975;