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Description for Protein SLC3A2

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
12 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06519
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    4F2; 4T2HC; NACAE; CD98HC; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform a; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform d; Antigen identified by monoclonal antibodies 4F2 TRA1.10 TROP4 and T43; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform b; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform e; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform f; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform c; MDU1; CD98; Antigen defined by monoclonal antibody 4F2, heavy chain; 4F2 heavy chain; 4F2HC; CD98 antigen; Monoclonal antibody 44D7; 4F2 cell surface antigen heavy chain; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 heavy chain
    Approved Symbol:
    SLC3A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 39
    Human (de-) phosphorylation sites: 39; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01148 Entrez Gene ID: 6520 OMIM ID: 158070 Swissprot Accession: P08195;