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Description for Protein SLC2A4

solute carrier family 2 (facilitated glucose transporter), member 4
40 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07191
    KEGG - Pathway(s):
    hsa04910; hsa04920; hsa04930
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glucose transporter 4; GLUT4
    Approved Symbol:
    SLC2A4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Diabetes mellitus, noninsulin-dependent(Pd)
    		• Predicted Transmembrane Domains:
    00688_1(12)
    Additional Identifiers:

    HPRD: 00688 Entrez Gene ID: 6517 OMIM ID: 138190 Swissprot Accession: P14672; Q05BQ3;