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Description for Protein SLC1A1

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05612
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Excitatory amino acid carrier 1; EAAC1; EAAT3; High affinity glutamate transporter; Sodium dependent glutamate/aspartate transporter 3; Neuronal and epithelial glutamate transporter; Neuronal/Epithelial high affinity glutamate transporter; Excitatory amino acid transporter 3
    Approved Symbol:
    SLC1A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Aspartic Acid(db);
  • L-Glutamic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 8
    • Additional Identifiers:

    HPRD: 00597 Entrez Gene ID: 6505 OMIM ID: 133550 Swissprot Accession: P43005;