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Description for Protein SKP1

S-phase kinase-associated protein 1
61 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 3)
Summary:
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SKP1: Found in Skp1 protein family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03094
    KEGG - Pathway(s):
    hsa04110; hsa04114; hsa04120; hsa04310; hsa04350
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SKP1; CDK2/Cyclin A associated protein p19A; EMC19; Organ of corti protein 2; OCP2; Transcription elongation factor B, 1 like; TCEB1L; MGC34403; OCP-II; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1; Transcription elongation factor B (SIII) polypeptide 1-like; p19skp1; p19A; S-phase kinase-associated protein 1A isoform b; S-phase kinase-associated protein 1A isoform a
    Approved Symbol:
    SKP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-2-(1H-indol-3-yl)hexanoic acid(db);
  • (2S)-2-(1H-indol-3-yl)pentanoic acid(db);
  • (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid(db);
  • 1H-INDOL-3-YLACETIC ACID(db);
  • Naphthalen-1-Yl-Acetic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03255 Entrez Gene ID: 6500 OMIM ID: 601434 Swissprot Accession: P63208;