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Description for Protein SIM2

single-minded homolog 2 (Drosophila)
6 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PAS: PAS domain
  • PAC: Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
  • NLS: Nuclear localization signal
  • HLH: helix loop helix domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09100
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SIM; Transcription factor SIM2; Single minded homolog 2 short isoform; Single minded homolog 2 long isoform
    Approved Symbol:
    SIM2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02935 Entrez Gene ID: 6493 OMIM ID: 600892 Swissprot Accession: Q14190;