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Description for Protein BMP1

bone morphogenetic protein 1
12 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • ZnMc: Zinc-dependent metalloprotease
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • EGFCA: Calcium-binding EGF-like domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.19
    KEGG - Orthology:
    K05502
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    TLD; Procollagen C-proteinase; PCP; Mammalian tolloid protein; mTld; Bone morphogenetic protein 1 isoform 2, precursor; Bone morphogenetic protein 1 isoform 3, precursor; Bone morphogenetic protein 1 isoform 1, precursor; PCOLC
    Approved Symbol:
    BMP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00209 Entrez Gene ID: 649 OMIM ID: 112264 Swissprot Accession: P13497;