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Description for Protein ST3GAL3

ST3 beta-galactoside alpha-2,3-sialyltransferase 3
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.99.6
    KEGG - Orthology:
    K00781
    KEGG - Pathway(s):
    hsa00533; hsa00601; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sialyltransferase 6 isoform a; Sialyltransferase 6 isoform j; Sialyltransferase 6 isoform b; Gal beta 1,3(4) GlcNAc alpha 2,3 sialyltransferase; ST3N; N acetyllactosaminide alpha 2,3 sialyltransferase; Alpha 2,3 sialyltransferase II; ST3GALII; SIAT6; ST3Gal III; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; EC 2.4.99.6; Sialyltransferase 6 isoform e; Sialyltransferase 6 isoform f; Sialyltransferase 6 isoform g; Sialyltransferase 6 isoform h; Sialyltransferase 6 isoform i; Sialyltransferase 6 isoform c; Sialyltransferase 6 isoform d
    Approved Symbol:
    ST3GAL3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    05930_11(1)
    05930_10(1)
  • Isoform 9 : 1
  • Isoform 8 : 1
  • Isoform 7 : 1
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 05930 Entrez Gene ID: 6487 OMIM ID: 606494 Swissprot Accession: Q96L53; Q11203; Q5T4Y1;