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Description for Protein USP46

ubiquitin specific peptidase 46
16 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • UCH: Ubiquitin carboxyl-terminal hydrolase
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.2.15
    KEGG - Orthology:
    K11842
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Ubiquitin carboxyl terminal hydrolase 46; Ubiquitin thiolesterase 46; Ubiquitin specific processing protease 46; Deubiquitinating enzyme 46; FLJ12552
    Approved Symbol:
    USP46
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07507 Entrez Gene ID: 64854 OMIM ID: 612849 Swissprot Accession: P62068;