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Description for Protein P2RY12

purinergic receptor P2Y, G-protein coupled, 12
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(membrane: 1; undefined: 1)
Summary:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04298
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    P2Y12; P2Y purinoceptor 12; Platelet ADP receptor; ADP glucose receptor; ADPG R HORK3 SP1999 P2Y(12) receptor P2Y(ADP); P2Y(AC); P2T(AC); HORK3; ADPG-R; SP1999; P2Y(ADP); P2Y(cyc); Purinergic receptor P2RY12; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; Putative G-protein coupled receptor; Purinergic receptor P2Y; G-protein coupled 12
    Approved Symbol:
    P2RY12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Clopidogrel(db);
  • Epoprostenol(db);
  • Prasugrel(db);
  • Ticlopidine(db);
  • Treprostinil(db)

    Associated Genetic Diseases:

  • Bleeding disorder due to P2RY12 defect(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 02743 Entrez Gene ID: 64805 OMIM ID: 600515 Swissprot Accession: Q9H244;