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Description for Protein ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 6; secretome: 1)
Summary:
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.99.1
    KEGG - Orthology:
    K00778
    KEGG - Pathway(s):
    hsa00510; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Beta-galactoside alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate beta-galactoside alpha-2,6-sialytransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase; Alpha 2,6-ST; B-cell antigen CD75; EC 2.4.99.1; ST6Gal I; Sialyltransferase 1 isoform b; Sialyltransferase 1 isoform a; SIAT1; ST6GalI; CD75; MGC48859
    Approved Symbol:
    ST6GAL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00184 Entrez Gene ID: 6480 OMIM ID: 109675 Swissprot Accession: P15907; B2R513;