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Description for Protein SIAH1

seven in absentia homolog 1 (Drosophila)
47 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RING: Ring finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K04506
    KEGG - Pathway(s):
    hsa04115; hsa04120; hsa04310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SIAH1-A; Seven in absentia homolog 1 isoform b; Seven in absentia homolog 1 isoform a; Seven in absentia homolog 1; Ubiquitin ligase SIAH1; HUMSIAH; Sonic hedgehog homolog
    Approved Symbol:
    SIAH1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Beta-Mercaptoethanol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03736 Entrez Gene ID: 6477 OMIM ID: 602212 Swissprot Accession: Q8IUQ4;