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Description for Protein SI

sucrase-isomaltase (alpha-glucosidase)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.10; 3.2.1.48
    KEGG - Orthology:
    K01203
    KEGG - Pathway(s):
    hsa00500; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sucrose alpha glucohydrolase; Sucrase; Sucrose alpha glucosidase
    Approved Symbol:
    SI
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acarbose(db);
  • Scopolamine(db)

    Associated Genetic Diseases:

  • Sucrase-isomaltase deficiency, congenital(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01962 Entrez Gene ID: 6476 OMIM ID: 609845 Swissprot Accession: P14410;