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Description for Protein SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.2.1
KEGG - Orthology:
K00600
KEGG - Pathway(s):
hsa00260; hsa00460; hsa00670; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glycine auxotroph A, human complement for hamster; GLY A+; Serine methylase; GLYA; Serine hydroxymethyltransferase 2; Glycine hydroxymethyltransferase; SHMT; EC 2.1.2.1
Approved Symbol:
SHMT2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glycine(db);
  • Pyridoxal Phosphate(db);
  • Tetrahydrofolic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00717 Entrez Gene ID: 6472 OMIM ID: 138450 Swissprot Accession: P34897; Q5BJF5; B4DJQ3;