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Description for Protein SHMT1

serine hydroxymethyltransferase 1 (soluble)
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 3)
Summary:
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.2.1
KEGG - Orthology:
K00600
KEGG - Pathway(s):
hsa00260; hsa00460; hsa00670; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Serine hydroxymethyltransferase 1; Serine methylase; hcSHMT; cSHMT; SHMT; Serine hydroxymethyltransferase; Glycine hydroxymethyltransferase; MGC15229; MGC24556; Serine hydroxymethyltransferase 1 (soluble); EC 2.1.2.1; 14 kDa protein; Cytoplasmic serine hydroxymethyltransferase; Serine hydroxymethyltransferase 1 (soluble) isoform 1; Serine hydroxymethyltransferase 1 (soluble) isoform 2
Approved Symbol:
SHMT1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-Hydroxymethylene-6-Hydrofolic Acid(db);
  • Glycine(db);
  • Mimosine(db);
  • N-Pyridoxyl-Glycine-5-Monophosphate(db);
  • Pyridoxal Phosphate(db);
  • Tetrahydrofolic acid(db);
  • Triglu-5-Formyl-Tetrahydrofolate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01643 Entrez Gene ID: 6470 OMIM ID: 182144 Swissprot Accession: P34896;