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Description for Protein ANAPC1

anaphase promoting complex subunit 1
16 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
ANAPC1 is 1 of at least 10 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03348
KEGG - Pathway(s):
hsa04110; hsa04114; hsa04120; hsa04914
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
MCPR; TSG24; APC1; Cyclosome subunit 1; Mitotic checkpoint regulator
Approved Symbol:
ANAPC1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 44
Human (de-) phosphorylation sites: 44; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09769 Entrez Gene ID: 64682 OMIM ID: 608473 Swissprot Accession: Q9H1A4;